' 
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (100% as Beta-Carotene)(from Blakeslea trispora and Sunflower Oil)
7,500 mcg
833%
Top Medical Research Studies
8
Vitamin A derivatives fight skin cancer
The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.
Highly relevant to skin cancer
We delved into the effects of retinoids, which are natural and synthetic derivatives of vitamin A, on skin cancer prevention and treatment. Non-melanoma skin cancers (NMSCs), a diverse group encompassing basal cell carcinoma and cutaneous squamous cell carcinoma, create significant challenges for patients and healthcare systems alike.
Through a comprehensive review, we observed how retinoids operate within the skin by influencing critical biological processes such as cell growth, differentiation, blood vessel formation, and immune responses. This modulation contributes to the suppression of skin cancer development.
Both topical and systemic forms of retinoids have been rigorously tested in clinical trials, showing promising efficacy and tolerability. As a result, regulatory authorities have sanctioned their use in managing NMSCs. Additionally, we noted acceptable off-label applications, expanding our understanding of these compounds in oncology.
Overall, our review highlighted the biochemistry of retinoids, their beneficial effects on skin physiology, and their therapeutic potential in clinical settings. This paints a hopeful picture for those at risk of or battling skin cancers.
Through a comprehensive review, we observed how retinoids operate within the skin by influencing critical biological processes such as cell growth, differentiation, blood vessel formation, and immune responses. This modulation contributes to the suppression of skin cancer development.
Both topical and systemic forms of retinoids have been rigorously tested in clinical trials, showing promising efficacy and tolerability. As a result, regulatory authorities have sanctioned their use in managing NMSCs. Additionally, we noted acceptable off-label applications, expanding our understanding of these compounds in oncology.
Overall, our review highlighted the biochemistry of retinoids, their beneficial effects on skin physiology, and their therapeutic potential in clinical settings. This paints a hopeful picture for those at risk of or battling skin cancers.
Read More
9
Vitamin A shows promise against cancer
All-trans retinoic acid exhibits anti-proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation.
High relevance to skin cancer treatment
We examined how all-trans retinoic acid (ATRA), a form of vitamin A, impacts Merkel cell carcinoma (MCC), a challenging and aggressive skin cancer. Our research focused on various MCC cell lines, both positive and negative for Merkel cell polyomavirus, to understand how ATRA influences cell behavior, including proliferation, viability, and migration.
ATRA demonstrated remarkable effects in slowing down the growth and survival of MCC cells. Notably, we observed a significant reduction in cell migration and the ability of these cancer cells to multiply. Additionally, ATRA was effective in disrupting the cell cycle and promoting cell death across all tested MCC cells. This signals a positive shift towards using retinoids in managing MCC.
Furthermore, our analyses revealed that ATRA works by enhancing certain pathways related to cell differentiation. This not only promotes the natural development of cells but also contributes to its anti-cancer effects by fostering environments where cancer growth is suppressed. Overall, our findings suggest that vitamin A derivatives like ATRA could pave the way for new treatments for those battling this aggressive skin cancer.
ATRA demonstrated remarkable effects in slowing down the growth and survival of MCC cells. Notably, we observed a significant reduction in cell migration and the ability of these cancer cells to multiply. Additionally, ATRA was effective in disrupting the cell cycle and promoting cell death across all tested MCC cells. This signals a positive shift towards using retinoids in managing MCC.
Furthermore, our analyses revealed that ATRA works by enhancing certain pathways related to cell differentiation. This not only promotes the natural development of cells but also contributes to its anti-cancer effects by fostering environments where cancer growth is suppressed. Overall, our findings suggest that vitamin A derivatives like ATRA could pave the way for new treatments for those battling this aggressive skin cancer.
Read More
9
Resveratrol improves skin cancer therapy
Resveratrol Can Differentiate Human Melanoma Stem-like Cells from Spheroids Treated With All-trans Retinoic Acid.
Clarifies vitamin A’s combined effectiveness
We explored how all-trans retinoic acid (ATRA), a form of vitamin A, interacts with resveratrol, a natural compound known for its health benefits, in treating resistant melanoma stem-like cells. The study specifically focused on these cells because they are linked to therapy resistance in malignant melanoma, a tough form of skin cancer.
By examining the responses of melanoma stem-like cells to ATRA alone and in combination with resveratrol, we found that many of these cancer cells showed resistance to ATRA treatment. However, when resveratrol was introduced alongside ATRA, the effectiveness of both treatments improved, suggesting that this combination could be a potential strategy for overcoming resistance to traditional therapy.
Through our analysis, we observed significant changes in the expression of certain markers associated with cancer stemness and differentiation. The combination therapy not only inhibited the stemness markers but also promoted differentiation in melanoma cells. In particular, combining resveratrol with ATRA led to better outcomes compared to using ATRA alone, which offers hope for enhancing the effectiveness of skin cancer treatments.
Overall, our findings highlight the potential of resveratrol to boost the responsiveness of melanoma stem-like cells to vitamin A treatment, paving the way for improved therapies against this challenging disease.
By examining the responses of melanoma stem-like cells to ATRA alone and in combination with resveratrol, we found that many of these cancer cells showed resistance to ATRA treatment. However, when resveratrol was introduced alongside ATRA, the effectiveness of both treatments improved, suggesting that this combination could be a potential strategy for overcoming resistance to traditional therapy.
Through our analysis, we observed significant changes in the expression of certain markers associated with cancer stemness and differentiation. The combination therapy not only inhibited the stemness markers but also promoted differentiation in melanoma cells. In particular, combining resveratrol with ATRA led to better outcomes compared to using ATRA alone, which offers hope for enhancing the effectiveness of skin cancer treatments.
Overall, our findings highlight the potential of resveratrol to boost the responsiveness of melanoma stem-like cells to vitamin A treatment, paving the way for improved therapies against this challenging disease.
Read More
Most Useful Reviews
8
Cat's ear healed
Worked for the cat. These capsules served their intended purpose, earning a 5-star rating. A cat was abandoned on our property, and after a vet visit, he started living in our breezeway to avoid bullies. This cat has one white ear, which unfortunately gets sunburned, leading to skin cancer. Thankfully, the vet caught the ear's sun damage early, advising a daily dose of beta-carotene or vitamin A. I opted for beta-carotene due to the distance to the vet for blood tests. I applied two capsules to the cat's food every morning and evening, with strict outdoor time restrictions to prevent sunbathing. Within two months, the ear healed, and he's now allowed out for limited time only, with no sun exposure.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
- All Researches
9
Resveratrol improves skin cancer therapy
Resveratrol Can Differentiate Human Melanoma Stem-like Cells from Spheroids Treated With All-trans Retinoic Acid.
Clarifies vitamin A’s combined effectiveness
We explored how all-trans retinoic acid (ATRA), a form of vitamin A, interacts with resveratrol, a natural compound known for its health benefits, in treating resistant melanoma stem-like cells. The study specifically focused on these cells because they are linked to therapy resistance in malignant melanoma, a tough form of skin cancer.
By examining the responses of melanoma stem-like cells to ATRA alone and in combination with resveratrol, we found that many of these cancer cells showed resistance to ATRA treatment. However, when resveratrol was introduced alongside ATRA, the effectiveness of both treatments improved, suggesting that this combination could be a potential strategy for overcoming resistance to traditional therapy.
Through our analysis, we observed significant changes in the expression of certain markers associated with cancer stemness and differentiation. The combination therapy not only inhibited the stemness markers but also promoted differentiation in melanoma cells. In particular, combining resveratrol with ATRA led to better outcomes compared to using ATRA alone, which offers hope for enhancing the effectiveness of skin cancer treatments.
Overall, our findings highlight the potential of resveratrol to boost the responsiveness of melanoma stem-like cells to vitamin A treatment, paving the way for improved therapies against this challenging disease.
By examining the responses of melanoma stem-like cells to ATRA alone and in combination with resveratrol, we found that many of these cancer cells showed resistance to ATRA treatment. However, when resveratrol was introduced alongside ATRA, the effectiveness of both treatments improved, suggesting that this combination could be a potential strategy for overcoming resistance to traditional therapy.
Through our analysis, we observed significant changes in the expression of certain markers associated with cancer stemness and differentiation. The combination therapy not only inhibited the stemness markers but also promoted differentiation in melanoma cells. In particular, combining resveratrol with ATRA led to better outcomes compared to using ATRA alone, which offers hope for enhancing the effectiveness of skin cancer treatments.
Overall, our findings highlight the potential of resveratrol to boost the responsiveness of melanoma stem-like cells to vitamin A treatment, paving the way for improved therapies against this challenging disease.
Read More
9
Vitamin A shows promise against cancer
All-trans retinoic acid exhibits anti-proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation.
High relevance to skin cancer treatment
We examined how all-trans retinoic acid (ATRA), a form of vitamin A, impacts Merkel cell carcinoma (MCC), a challenging and aggressive skin cancer. Our research focused on various MCC cell lines, both positive and negative for Merkel cell polyomavirus, to understand how ATRA influences cell behavior, including proliferation, viability, and migration.
ATRA demonstrated remarkable effects in slowing down the growth and survival of MCC cells. Notably, we observed a significant reduction in cell migration and the ability of these cancer cells to multiply. Additionally, ATRA was effective in disrupting the cell cycle and promoting cell death across all tested MCC cells. This signals a positive shift towards using retinoids in managing MCC.
Furthermore, our analyses revealed that ATRA works by enhancing certain pathways related to cell differentiation. This not only promotes the natural development of cells but also contributes to its anti-cancer effects by fostering environments where cancer growth is suppressed. Overall, our findings suggest that vitamin A derivatives like ATRA could pave the way for new treatments for those battling this aggressive skin cancer.
ATRA demonstrated remarkable effects in slowing down the growth and survival of MCC cells. Notably, we observed a significant reduction in cell migration and the ability of these cancer cells to multiply. Additionally, ATRA was effective in disrupting the cell cycle and promoting cell death across all tested MCC cells. This signals a positive shift towards using retinoids in managing MCC.
Furthermore, our analyses revealed that ATRA works by enhancing certain pathways related to cell differentiation. This not only promotes the natural development of cells but also contributes to its anti-cancer effects by fostering environments where cancer growth is suppressed. Overall, our findings suggest that vitamin A derivatives like ATRA could pave the way for new treatments for those battling this aggressive skin cancer.
Read More
9
ATRA enhances melanoma treatment efficacy
Targeting MDSC Differentiation Using ATRA: A Phase I/II Clinical Trial Combining Pembrolizumab and All-Trans Retinoic Acid for Metastatic Melanoma.
Effectiveness combined with pembrolizumab
We undertook a clinical trial pairing all-trans retinoic acid (ATRA), a form of vitamin A, with pembrolizumab—a PD-1 inhibitor—in patients battling stage IV melanoma. This study specifically aimed to see if the combination could enhance safety and effectiveness in treating advanced skin cancer while also targeting certain immune cells known to inhibit cancer-fighting responses.
In our study, 24 patients were treated, most of whom had not received prior therapies for their melanoma. We prioritized identifying the maximum tolerated dose of this combination and assessing its side effects and overall effectiveness. Notably, we found that 71% of participants responded positively to the treatment—half of them even achieving a complete response. Additionally, the combination successfully reduced levels of myeloid-derived suppressor cells, which are known to hamper immune activity against tumors.
Our results indicated a median progression-free survival of 20.3 months, along with an impressive one-year overall survival rate of 80%. While we could not isolate the effects of vitamin A treatment alone from the combination therapy, the findings show that targeting tumor immunity could make a significant difference in melanoma treatment.
In our study, 24 patients were treated, most of whom had not received prior therapies for their melanoma. We prioritized identifying the maximum tolerated dose of this combination and assessing its side effects and overall effectiveness. Notably, we found that 71% of participants responded positively to the treatment—half of them even achieving a complete response. Additionally, the combination successfully reduced levels of myeloid-derived suppressor cells, which are known to hamper immune activity against tumors.
Our results indicated a median progression-free survival of 20.3 months, along with an impressive one-year overall survival rate of 80%. While we could not isolate the effects of vitamin A treatment alone from the combination therapy, the findings show that targeting tumor immunity could make a significant difference in melanoma treatment.
Read More
8
Vitamin A derivatives fight skin cancer
The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.
Highly relevant to skin cancer
We delved into the effects of retinoids, which are natural and synthetic derivatives of vitamin A, on skin cancer prevention and treatment. Non-melanoma skin cancers (NMSCs), a diverse group encompassing basal cell carcinoma and cutaneous squamous cell carcinoma, create significant challenges for patients and healthcare systems alike.
Through a comprehensive review, we observed how retinoids operate within the skin by influencing critical biological processes such as cell growth, differentiation, blood vessel formation, and immune responses. This modulation contributes to the suppression of skin cancer development.
Both topical and systemic forms of retinoids have been rigorously tested in clinical trials, showing promising efficacy and tolerability. As a result, regulatory authorities have sanctioned their use in managing NMSCs. Additionally, we noted acceptable off-label applications, expanding our understanding of these compounds in oncology.
Overall, our review highlighted the biochemistry of retinoids, their beneficial effects on skin physiology, and their therapeutic potential in clinical settings. This paints a hopeful picture for those at risk of or battling skin cancers.
Through a comprehensive review, we observed how retinoids operate within the skin by influencing critical biological processes such as cell growth, differentiation, blood vessel formation, and immune responses. This modulation contributes to the suppression of skin cancer development.
Both topical and systemic forms of retinoids have been rigorously tested in clinical trials, showing promising efficacy and tolerability. As a result, regulatory authorities have sanctioned their use in managing NMSCs. Additionally, we noted acceptable off-label applications, expanding our understanding of these compounds in oncology.
Overall, our review highlighted the biochemistry of retinoids, their beneficial effects on skin physiology, and their therapeutic potential in clinical settings. This paints a hopeful picture for those at risk of or battling skin cancers.
Read More
7
Alitretinoin shows potential in CTCL
Alitretinoin in the treatment of cutaneous T-cell lymphoma.
Combination treatment complicates evaluation
We sought to understand how vitamin A, in the form of alitretinoin, impacts skin cancer, specifically looking at the most common types of cutaneous T-cell lymphomas (CTCLs).
Over a seven-year period, we examined the medical records of 35 patients, predominantly diagnosed with mycosis fungoides (MF) and Sézary syndrome (SS). Our findings revealed that about 37% of patients showed a positive response to alitretinoin, while another 29% maintained stable disease. Unfortunately, nearly a third experienced disease progression during the study.
We noted that while many patients tolerated the treatment well, with 63% reporting no side effects, the most common issue was elevated triglycerides. Notably, alitretinoin was frequently combined with other therapies, making it difficult to pinpoint its exact impact on skin cancer independently.
Overall, our study suggests that alitretinoin could be a viable option for treating less advanced CTCLs due to its low side-effect profile and affordability compared to other medications.
Over a seven-year period, we examined the medical records of 35 patients, predominantly diagnosed with mycosis fungoides (MF) and Sézary syndrome (SS). Our findings revealed that about 37% of patients showed a positive response to alitretinoin, while another 29% maintained stable disease. Unfortunately, nearly a third experienced disease progression during the study.
We noted that while many patients tolerated the treatment well, with 63% reporting no side effects, the most common issue was elevated triglycerides. Notably, alitretinoin was frequently combined with other therapies, making it difficult to pinpoint its exact impact on skin cancer independently.
Overall, our study suggests that alitretinoin could be a viable option for treating less advanced CTCLs due to its low side-effect profile and affordability compared to other medications.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Cat's ear healed
Worked for the cat. These capsules served their intended purpose, earning a 5-star rating. A cat was abandoned on our property, and after a vet visit, he started living in our breezeway to avoid bullies. This cat has one white ear, which unfortunately gets sunburned, leading to skin cancer. Thankfully, the vet caught the ear's sun damage early, advising a daily dose of beta-carotene or vitamin A. I opted for beta-carotene due to the distance to the vet for blood tests. I applied two capsules to the cat's food every morning and evening, with strict outdoor time restrictions to prevent sunbathing. Within two months, the ear healed, and he's now allowed out for limited time only, with no sun exposure.
Read More
